Yang Lab in the department of Orthopaedic Surgery

Welcome to Dr. Yunzhi Peter Yang’s Group at Stanford University.

Globally, musculoskeletal diseases and trauma have an estimated cost of US$950 billion annually, placing a significant economic burden on national healthcare systems. Musculoskeletal ailments severely impact mobility, dramatically reducing the quality of life for patients, especially the elderly. Regenerative medicine and tissue engineering hold great promise to improve the treatment of these diseases and trauma as well as to restore lost functions. Despite great progress in the past twenty years, we have gradually come to the consensus that the great complexity of tissue regeneration requires we approach problems in a systematic way in order to make breakthroughs. Currently, there are still three fundamental questions in tissue engineering that hinder translation and clinical success, including how to recreate microenvironments to control cell fate, how to promote vascularization for cell viability, and how to harness stem cells as cell source. More specifically, regarding microenvironments, how do we engineer a microenvironment to include both scaffold and signals, or accurately manipulate 3D biochemical, biophysical, biomechanical, bioelectrical and biomagnetic cell cues in a temporal and spatial manner to accelerate tissue regeneration and healing? Second, regarding vascularization, how do we meet the functional microvasculature requirement in which the distance between an individual cell and the nearest capillary vessels cannot be more than 100-300 μm or else the cell will suffer from insufficient nutrition and oxygen? Third, regarding stem cells, what is the origin of stem/progenitor cells and how fast and how many stem/progenitor cells can grow in a clinically relevant setting? In our lab, we use bio-inspired approaches to systematically address these challenges by integrating the expertise in materials science and engineering, chemistry, bone and stem cell biology, and orthopedic surgery.



September 2016: Dr. Yang received a new 5-year NIH award for systematic modeling guided bone regeneration!

September 2016: Congrats to Drs. Shanjani and Ker for publishing their work entitled "Endothelial pattern formation in hybrid constructs of additive manufactured porous rigid scaffolds and cell-laden hydrogels for orthopedic applications' in the Journal of Mechanical Behavior of Biomedical Materials!

August 2016: Dr. Yang's 3D printing technology has contributed to Professor Dauskardt's innovative research award in clean energy!

August 2016: Congrats to Chi-chun Jerry Pan for his invention in bioprinting technology!

August 2016: Our invited review paper entitled "Vascularization of tissue engineering bone constructs" received the Editorial Award of Annals of Biomedical Engineering for the most citations of the year!

August 2016: Congrats to Chi-chun Jerry Pan and Dr. Bruyas for publishing their invited review paper entitled "Bioprinting for tissue engineering and regenerative medicine"!

May 2016: Dr. Yang received the Coulter Translational Seed Grant!

March 2016: Congrats to Dr. Elmer Ker for his invention of novel biomaterials!

March 2016: Congrats to Dr. Laura Elomma for the best doctoral thesis award of the year!

December 2015: Congrats to Dr. Sungwoo Kim for successful tranferring his drug delivery technology to pharmaceutical company!

August 2015: Dr. Yang received a NIH Star Award for stem cell research!

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